HIV Target gene Detail Information

> SERPINB1 Gene Search Result

Gene Information

Gene Name	SERPINB1
Gene ID	1992
Gene Full Name	serpin family B member 1
Gene Alias	EI; LEI; PI2; MNEI; PI-2; HEL57; M/NEI; ELANH2; HEL-S-27
Transcripts	ENSG00000021355
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytoplasmic bodies;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	P30740
HGNC ID	HGNC:3311
VEGA ID	OTTHUMG00000014124
OMIM ID	130135
String ID	9606.ENSP00000370115
PharmGKB ID	PA35046

Target gene [SERPINB1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001681	chr6	26	111	3	140	View
4006209	chr6	19	7		26	View
4007301	chr6	14	6		20	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SERPINB1 expression and immune infiltrating cell level correlation result in HIV+ samples
SERPINB1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SERPINB1 expression and immune infiltrating cell level correlation result in HIV+ samples
SERPINB1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).