HTLV1 Target gene Detail Information

> SERPINA6 Gene Search Result

Gene Information

Gene Name	SERPINA6
Gene ID	866
Gene Full Name	serpin family A member 6
Gene Alias	CBG
Transcripts	ENSG00000277405
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P08185
HGNC ID	HGNC:1540
VEGA ID	OTTHUMG00000190242
OMIM ID	122500
String ID	9606.ENSP00000342850
Drugbank ID	BE0000209
PharmGKB ID	PA35033

Target gene [SERPINA6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001070	chr14	106	447	50	603	View
6001238	chr14	49	432	39	520	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SERPINA6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SERPINA6 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SERPINA6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SERPINA6 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SERPINA6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SERPINA6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).