HBV Target gene Detail Information

> SERPINA1 Gene Search Result

Gene Information

Gene Name	SERPINA1
Gene ID	5265
Gene Full Name	serpin family A member 1
Gene Alias	PI; A1A; AAT; PI1; A1AT; nNIF; PRO2275; alpha1AT
Transcripts	ENSG00000277377
Virus	HBV
Gene Type	protein coding
HPA Location Info	Vesicles;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P01009
HGNC ID	HGNC:8941
VEGA ID	OTTHUMG00000190244
OMIM ID	107400
String ID	9606.ENSP00000416066
Drugbank ID	BE0000952
PharmGKB ID	PA35509

Target gene [SERPINA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1005251	chr14	50	7	1	58	View
1005519	chr14	47	5	1	53	View
1007244	chr14	9	9	11	29	View
1008017	chr14	9	8	6	23	View
1008018	chr14	10	6	7	23	View
1009445	chr14	15	1		16	View
1010533	chr14	11		1	12	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SERPINA1 expression and immune infiltrating cell level correlation result in HBV+ samples
SERPINA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).