HTLV1 Target gene Detail Information

> SERINC2 Gene Search Result

Gene Information

Gene Name	SERINC2
Gene ID	347735
Gene Full Name	serine incorporator 2
Gene Alias	TDE2; TDE2L; FKSG84; PRO0899
Transcripts	ENSG00000168528
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Plasma membrane;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins
Uniport_ID	Q96SA4
HGNC ID	HGNC:23231
VEGA ID	OTTHUMG00000003796
OMIM ID	614549
String ID	9606.ENSP00000362814
PharmGKB ID	PA134933002

Target gene [SERINC2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6007745	chr1	41	11		52	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SERINC2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SERINC2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SERINC2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SERINC2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SERINC2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SERINC2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).