HIV Target gene Detail Information

> SEPSECS Gene Search Result

Gene Information

Gene Name	SEPSECS
Gene ID	51091
Gene Full Name	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Gene Alias	LP; SLA; PCH2D; SLA/LP
Transcripts	ENSG00000109618
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q9HD40
HGNC ID	HGNC:30605
VEGA ID	OTTHUMG00000128563
OMIM ID	613009
String ID	9606.ENSP00000371535
Drugbank ID	BE0002171
PharmGKB ID	PA162402915

Target gene [SEPSECS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009261	chr4	7	5		12	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SEPSECS expression and immune infiltrating cell level correlation result in HIV+ samples
SEPSECS expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SEPSECS expression and immune infiltrating cell level correlation result in HIV+ samples
SEPSECS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).