HTLV1 Target gene Detail Information

> SEMA6A Gene Search Result

Gene Information

Gene Name	SEMA6A
Gene ID	57556
Gene Full Name	semaphorin 6A
Gene Alias	VIA; SEMA; HT018; SEMAQ; SEMA6A1
Transcripts	ENSG00000092421
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Intermediate filaments;Nuclear bodies;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9H2E6
HGNC ID	HGNC:10738
VEGA ID	OTTHUMG00000162987
OMIM ID	605885
String ID	9606.ENSP00000257414
PharmGKB ID	PA35660

Target gene [SEMA6A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6005348	chr5	79	10		89	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SEMA6A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SEMA6A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SEMA6A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SEMA6A expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SEMA6A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SEMA6A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).