HIV Target gene Detail Information

> SEMA4D Gene Search Result

Gene Information

Gene Name	SEMA4D
Gene ID	10507
Gene Full Name	semaphorin 4D
Gene Alias	CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G
Transcripts	ENSG00000187764
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q92854
HGNC ID	HGNC:10732
VEGA ID	OTTHUMG00000020185
OMIM ID	601866
String ID	9606.ENSP00000416523
PharmGKB ID	PA35654

Target gene [SEMA4D] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000758	chr9	280	8		288	View
4002725	chr9	78	2	2	82	View
4006390	chr9	18	4	3	25	View
4013752	chr9	2		1	3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SEMA4D expression and immune infiltrating cell level correlation result in HIV+ samples
SEMA4D expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SEMA4D expression and immune infiltrating cell level correlation result in HIV+ samples
SEMA4D expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).