HIV Target gene Detail Information

> SEC63 Gene Search Result

Gene Information

Gene Name	SEC63
Gene ID	11231
Gene Full Name	SEC63 homolog, protein translocation regulator
Gene Alias	ERdj2; PCLD2; SEC63L; DNAJC23; PRO2507
Transcripts	ENSG00000025796
Virus	HIV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID	Q9UGP8
HGNC ID	HGNC:21082
VEGA ID	OTTHUMG00000015316
OMIM ID	608648
String ID	9606.ENSP00000357998
PharmGKB ID	PA134936990

Target gene [SEC63] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4007471	chr6	4		15	19	View
4010761	chr6	6	2		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SEC63 expression and immune infiltrating cell level correlation result in HIV+ samples
SEC63 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SEC63 expression and immune infiltrating cell level correlation result in HIV+ samples
SEC63 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).