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HTLV1 Target gene Detail Information

> SEC11C Gene Search Result


Gene Information
Gene Name SEC11C
Gene ID 90701
Gene Full Name SEC11 homolog C, signal peptidase complex subunit
Gene Alias SPC21; SPCS4C; SEC11L3
Transcripts ENSG00000166562
Virus HTLV1
Gene Type protein coding
HPA Location Info Nuclear membrane;Golgi apparatus;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Predicted membrane proteins
Uniport_ID Q9BY50
HGNC ID HGNC:23400
VEGA ID OTTHUMG00000132762
String ID 9606.ENSP00000468633
PharmGKB ID PA162402587
Target gene [SEC11C] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6008323 chr18 23 17 6 46 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of SEC11C expression and immune infiltrating cell level correlation result in HTLV1+ samples
SEC11C expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of SEC11C expression and immune infiltrating cell level correlation result in HTLV1+ samples
SEC11C expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).