HIV Target gene Detail Information

> SEC11A Gene Search Result

Gene Information

Gene Name	SEC11A
Gene ID	23478
Gene Full Name	SEC11 homolog A, signal peptidase complex subunit
Gene Alias	SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
Transcripts	ENSG00000140612
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear membrane;Golgi apparatus;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P67812
HGNC ID	HGNC:17718
VEGA ID	OTTHUMG00000172489
OMIM ID	618258
String ID	9606.ENSP00000452697
PharmGKB ID	PA162402586

Target gene [SEC11A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004056	chr15	39	7	4	50	View
4004913	chr15	27	10	1	38	View
4009016	chr15	2	11		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SEC11A expression and immune infiltrating cell level correlation result in HIV+ samples
SEC11A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SEC11A expression and immune infiltrating cell level correlation result in HIV+ samples
SEC11A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).