HBV Target gene Detail Information

> SDSL Gene Search Result

Gene Information

Gene Name	SDSL
Gene ID	113675
Gene Full Name	serine dehydratase like
Gene Alias	TDH; cSDH; SDH 2; SDS-RS1
Transcripts	ENSG00000139410
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q96GA7
HGNC ID	HGNC:30404
VEGA ID	OTTHUMG00000169551
String ID	9606.ENSP00000385790
Drugbank ID	BE0002168
PharmGKB ID	PA134862016

Target gene [SDSL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1404300	chr12	2494	82	15	2591	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of SDSL expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
SDSL expression: Low -> High
Lollipop of SDSL expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of SDSL expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SDSL expression and immune infiltrating cell level correlation result in HBV+ samples
SDSL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).