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HBV Target gene Detail Information

> SDS Gene Search Result


Gene Information
Gene Name SDS
Gene ID 10993
Gene Full Name serine dehydratase
Gene Alias SDH
Transcripts ENSG00000135094
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Mitochondria;
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID P20132
HGNC ID HGNC:10691
VEGA ID OTTHUMG00000169554
OMIM ID 182128
String ID 9606.ENSP00000257549
Drugbank ID BE0000164
PharmGKB ID PA35616
Target gene [SDS] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001566 chr12 159 204 251 614 View
1400066 chr12 30 8 2 40 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of SDS expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
SDS expression: Low -> High
Lollipop of SDS expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of SDS expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SDS expression and immune infiltrating cell level correlation result in HBV+ samples
SDS expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).