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EBV Target gene Detail Information

> SDHB Gene Search Result


Gene Information
Gene Name SDHB
Gene ID 6390
Gene Full Name succinate dehydrogenase complex iron sulfur subunit B
Gene Alias IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
Transcripts ENSG00000117118
Virus EBV
Gene Type protein coding
HPA Location Info Mitochondria;Nucleoplasm;Plasma membrane;
HPA Protein Class Info Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Gene Function Suppressor gene
Uniport_ID P21912
HGNC ID HGNC:10681
VEGA ID OTTHUMG00000002289
OMIM ID 185470
String ID 9606.ENSP00000364649
Drugbank ID BE0002254; BE0003845
PharmGKB ID PA35606
Target gene [SDHB] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3000152 chr1 105 105 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE102203 (GEO) B-cell lymphoma 9 Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE100458 (GEO) Burkitt lymphoma 14 Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)
GSE42867 (GEO) Burkitt lymphoma 12 Burkitt lymphoma cell line Awia (EBV+)(12)
GSE135644 (GEO) Gastric carcinoma 10 Gastric adenocarcinoma cell line AGS (5), Gastric adenocarcinoma cell line AGS (EBV+)(5)
GSE45919 (GEO) Infectious mononucleosis 24 Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO) Infectious mononucleosis 17 Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO) Multiple sclerosis 32 Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)
GSE12452 (GEO) Nasopharyngeal carcinoma 41 Nasopharyngeal carcinoma (EBV+)(31), Normal(10)

> Dataset: GSE102203

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High

> Dataset: GSE100458

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High

> Dataset: GSE42867

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High

> Dataset: GSE135644

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High

> Dataset: GSE45919

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High

> Dataset: GSE85599

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High

> Dataset: GSE58240

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High

> Dataset: GSE12452

HeatMap of cell type fractions in all samples Lollipop of SDHB expression and immune infiltrating cell level correlation result in EBV+ samples
SDHB expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).