HIV Target gene Detail Information

> SDHA Gene Search Result

Gene Information

Gene Name	SDHA
Gene ID	6389
Gene Full Name	succinate dehydrogenase complex flavoprotein subunit A
Gene Alias	FP; PGL5; SDH1; SDH2; SDHF; CMD1GG
Transcripts	ENSG00000073578
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;Nucleoli;
HPA Protein Class Info	Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P31040
HGNC ID	HGNC:10680
VEGA ID	OTTHUMG00000090275
OMIM ID	600857
String ID	9606.ENSP00000264932
Drugbank ID	BE0000176; BE0003342
PharmGKB ID	PA35605

Target gene [SDHA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004376	chr5	44	1		45	View
4005097	chr5	33	3		36	View
4011771	chr5	4	2		6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SDHA expression and immune infiltrating cell level correlation result in HIV+ samples
SDHA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SDHA expression and immune infiltrating cell level correlation result in HIV+ samples
SDHA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).