HIV Target gene Detail Information

> SCYL1 Gene Search Result

Gene Information

Gene Name	SCYL1
Gene ID	57410
Gene Full Name	SCY1 like pseudokinase 1
Gene Alias	GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; SCAR21
Transcripts	ENSG00000142186
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q96KG9
HGNC ID	HGNC:14372
VEGA ID	OTTHUMG00000166325
OMIM ID	607982
String ID	9606.ENSP00000270176
Drugbank ID	BE0002479
PharmGKB ID	PA31812

Target gene [SCYL1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004297	chr11	46			46	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SCYL1 expression and immune infiltrating cell level correlation result in HIV+ samples
SCYL1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SCYL1 expression and immune infiltrating cell level correlation result in HIV+ samples
SCYL1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).