HIV Target gene Detail Information

> SCRIB Gene Search Result

Gene Information

Gene Name	SCRIB
Gene ID	23513
Gene Full Name	scribbled planar cell polarity protein
Gene Alias	CRIB1; SCRB1; SCRIB1; Vartul
Transcripts	ENSG00000274287
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cell Junctions;Plasma membrane;Nucleoplasm;Rods & Rings;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q14160
HGNC ID	HGNC:30377
VEGA ID	OTTHUMG00000190686
OMIM ID	607733
String ID	9606.ENSP00000349486
PharmGKB ID	PA134936275

Target gene [SCRIB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003458	chr8	56	4	1	61	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SCRIB expression and immune infiltrating cell level correlation result in HIV+ samples
SCRIB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SCRIB expression and immune infiltrating cell level correlation result in HIV+ samples
SCRIB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).