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HTLV1 Target gene Detail Information

> SCN8A Gene Search Result


Gene Information
Gene Name SCN8A
Gene ID 6334
Gene Full Name sodium voltage-gated channel alpha subunit 8
Gene Alias MED; PN4; CIAT; BFIS5; NaCh6; CERIII; EIEE13; Nav1.6
Transcripts ENSG00000196876
Virus HTLV1
Gene Type protein coding
HPA Location Info Plasma membrane;Cell Junctions;Vesicles;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID Q9UQD0
HGNC ID HGNC:10596
VEGA ID OTTHUMG00000169490
OMIM ID 600702
String ID 9606.ENSP00000346534
Drugbank ID BE0002084; BE0009738; BE0004901
PharmGKB ID PA35009
Target gene [SCN8A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6015354 chr12 1 13 14 View
6025329 chr12 1 2 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of SCN8A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN8A expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of SCN8A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN8A expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of SCN8A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN8A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).