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HTLV1 Target gene Detail Information

> SCN4A Gene Search Result


Gene Information
Gene Name SCN4A
Gene ID 6329
Gene Full Name sodium voltage-gated channel alpha subunit 4
Gene Alias HYPP; SkM1; CMS16; HYKPP; NAC1A; HOKPP2; Nav1.4; Na(V)1.4
Transcripts ENSG00000007314
Virus HTLV1
Gene Type protein coding
HPA Location Info Nucleoplasm;Centriolar satellite;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID P35499
HGNC ID HGNC:10591
VEGA ID OTTHUMG00000179046
OMIM ID 603967
String ID 9606.ENSP00000396320
Drugbank ID BE0002083; BE0009738; BE0004901
PharmGKB ID PA35006
Target gene [SCN4A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6002587 chr17 11 73 143 227 View
6002588 chr17 11 73 143 227 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of SCN4A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN4A expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of SCN4A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN4A expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of SCN4A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN4A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).