HTLV1 Target gene Detail Information

> SCN2A Gene Search Result

Gene Information

Gene Name	SCN2A
Gene ID	6326
Gene Full Name	sodium voltage-gated channel alpha subunit 2
Gene Alias	HBA; NAC2; BFIC3; BFIS3; BFNIS; HBSCI; EIEE11; HBSCII; Nav1.2; SCN2A1; SCN2A2; Na(v)1.2
Transcripts	ENSG00000136531
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID	Q99250
HGNC ID	HGNC:10588
VEGA ID	OTTHUMG00000044172
OMIM ID	182390
String ID	9606.ENSP00000364586
Drugbank ID	BE0002081; BE0009738; BE0004901
PharmGKB ID	PA35004

Target gene [SCN2A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6009470	chr2	32	1	4	37	View
6028993	chr2	1			1	View
6029677	chr2		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SCN2A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN2A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SCN2A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN2A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).