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HTLV1 Target gene Detail Information

> SCN10A Gene Search Result


Gene Information
Gene Name SCN10A
Gene ID 6336
Gene Full Name sodium voltage-gated channel alpha subunit 10
Gene Alias PN3; SNS; hPN3; FEPS2; Nav1.8
Transcripts ENSG00000185313
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels
Uniport_ID Q9Y5Y9
HGNC ID HGNC:10582
VEGA ID OTTHUMG00000048245
OMIM ID 604427
String ID 9606.ENSP00000390600
Drugbank ID BE0000177; BE0009738; BE0004901
PharmGKB ID PA35000
Target gene [SCN10A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6007054 chr3 56 3 1 60 View
6027282 chr3 1 1 2 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of SCN10A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN10A expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of SCN10A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN10A expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of SCN10A expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCN10A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).