HTLV1 Target gene Detail Information

> SCG3 Gene Search Result

Gene Information

Gene Name	SCG3
Gene ID	29106
Gene Full Name	secretogranin III
Gene Alias	SGIII
Transcripts	ENSG00000104112
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;Predicted to be secreted;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	Q8WXD2
HGNC ID	HGNC:13707
VEGA ID	OTTHUMG00000131748
OMIM ID	611796
String ID	9606.ENSP00000220478
PharmGKB ID	PA34988

Target gene [SCG3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006762	chr15	61	2		63	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of SCG3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCG3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of SCG3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCG3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of SCG3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
SCG3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).