HBV Target gene Detail Information

> SASH1 Gene Search Result

Gene Information

Gene Name	SASH1
Gene ID	23328
Gene Full Name	SAM and SH3 domain containing 1
Gene Alias	SH3D6A; dJ323M4.1
Transcripts	ENSG00000111961
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	O94885
HGNC ID	HGNC:19182
VEGA ID	OTTHUMG00000015773
OMIM ID	607955
String ID	9606.ENSP00000356437
PharmGKB ID	PA134984521

Target gene [SASH1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1000840	chr6	233	720	409	1362	View
1008478	chr6	20			20	View
1010912	chr6	10			10	View
1013319	chr6	5			5	View
1403656	chr6	20			20	View
1403657	chr6	10			10	View
1404550	chr6	26			26	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of SASH1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
SASH1 expression: Low -> High
Lollipop of SASH1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of SASH1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of SASH1 expression and immune infiltrating cell level correlation result in HBV+ samples
SASH1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).