HIV Target gene Detail Information

> SAE1 Gene Search Result

Gene Information

Gene Name	SAE1
Gene ID	10055
Gene Full Name	SUMO1 activating enzyme subunit 1
Gene Alias	AOS1; SUA1; UBLE1A; HSPC140
Transcripts	ENSG00000142230
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9UBE0
HGNC ID	HGNC:30660
VEGA ID	OTTHUMG00000183464
OMIM ID	613294
String ID	9606.ENSP00000270225
PharmGKB ID	PA162402387

Target gene [SAE1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000236	chr19	58	412	200	670	View
4000237	chr19	151	461	54	666	View
4001590	chr19	108		41	149	View
4001609	chr19	146	1		147	View
4003273	chr19	48	7	10	65	View
4004010	chr19	4	2	45	51	View
4005871	chr19	29			29	View
4006642	chr19	18	4	1	23	View
4007202	chr19	11	9		20	View
4008610	chr19	12	2		14	View
4008953	chr19	12	1		13	View
4009672	chr19	11			11	View
4010048	chr19	10			10	View
4011080	chr19	7			7	View
4011081	chr19	7			7	View
4012808	chr19	3		1	4	View
4013184	chr19	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of SAE1 expression and immune infiltrating cell level correlation result in HIV+ samples
SAE1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of SAE1 expression and immune infiltrating cell level correlation result in HIV+ samples
SAE1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).