HPV Target gene Detail Information

> S100A2 Gene Search Result

Gene Information

Gene Name	S100A2
Gene ID	6273
Gene Full Name	S100 calcium binding protein A2
Gene Alias	CAN19; S100L
Transcripts	ENSG00000196754
Virus	HPV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Nucleoli;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P29034
HGNC ID	HGNC:10492
VEGA ID	OTTHUMG00000035031
OMIM ID	176993
String ID	9606.ENSP00000357697
Drugbank ID	BE0003602
PharmGKB ID	PA34904

Target gene [S100A2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5402693	chr1	241	1043	970	2254	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of S100A2 expression and immune infiltrating cell level correlation result in HPV+ samples
S100A2 expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of S100A2 expression and immune infiltrating cell level correlation result in HPV+ samples
S100A2 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of S100A2 expression and immune infiltrating cell level correlation result in HPV+ samples
S100A2 expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of S100A2 expression and immune infiltrating cell level correlation result in HPV+ samples
S100A2 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of S100A2 expression and immune infiltrating cell level correlation result in HPV+ samples
S100A2 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of S100A2 expression and immune infiltrating cell level correlation result in HPV+ samples
S100A2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE65858