HIV Target gene Detail Information

> RYR1 Gene Search Result

Gene Information

Gene Name	RYR1
Gene ID	6261
Gene Full Name	ryanodine receptor 1
Gene Alias	CCO; MHS; RYR; MHS1; RYDR; SKRR; RYR-1; PPP1R137
Transcripts	ENSG00000196218
Virus	HIV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Vesicles;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P21817
HGNC ID	HGNC:10483
VEGA ID	OTTHUMG00000182403
OMIM ID	180901
String ID	9606.ENSP00000352608
Drugbank ID	BE0000739
PharmGKB ID	PA34896
FDA Approved Drug	Sevoflurane

Target gene [RYR1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003494	chr19	4	55	1	60	View
4015323	chr19	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of RYR1 expression and immune infiltrating cell level correlation result in HIV+ samples
RYR1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of RYR1 expression and immune infiltrating cell level correlation result in HIV+ samples
RYR1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).