HTLV1 Target gene Detail Information

> RS1 Gene Search Result

Gene Information

Gene Name	RS1
Gene ID	6247
Gene Full Name	retinoschisin 1
Gene Alias	RS; XLRS1
Transcripts	ENSG00000102104
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Predicted secreted proteins
Uniport_ID	O15537
HGNC ID	HGNC:10457
VEGA ID	OTTHUMG00000021216
OMIM ID	300839
String ID	9606.ENSP00000369320
PharmGKB ID	PA34871

Target gene [RS1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000047	chr1	4112	1394	1021	6527	View
6000722	chr11	898	20	14	932	View
6003278	chr11	165	5		170	View
6004324	chr2	58	39	23	120	View
6004866	chr1	71	25	6	102	View
6008025	chr5	33	2	14	49	View
6010294	chr1	2	7	23	32	View
6015280	chr5	3	11		14	View
6019344	chr1	6	2		8	View
6024621	chr1		3		3	View
6025587	chrX	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of RS1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
RS1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of RS1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
RS1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of RS1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
RS1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).