HIV Target gene Detail Information

> RPS6KA3 Gene Search Result

Gene Information

Gene Name	RPS6KA3
Gene ID	6197
Gene Full Name	ribosomal protein S6 kinase A3
Gene Alias	CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
Transcripts	ENSG00000177189
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Nucleoli;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P51812
HGNC ID	HGNC:10432
VEGA ID	OTTHUMG00000021231
OMIM ID	300075
String ID	9606.ENSP00000368884
Drugbank ID	BE0004825
PharmGKB ID	PA34847

Target gene [RPS6KA3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005766	chrX	30			30	View
4010362	chrX	9			9	View
4011121	chrX	6	1		7	View
4012171	chrX	4	1		5	View
4012787	chrX	1	3		4	View
4300103	chrX	3	1	1	5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of RPS6KA3 expression and immune infiltrating cell level correlation result in HIV+ samples
RPS6KA3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of RPS6KA3 expression and immune infiltrating cell level correlation result in HIV+ samples
RPS6KA3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).