HTLV1 Target gene Detail Information

> ROR2 Gene Search Result

Gene Information

Gene Name	ROR2
Gene ID	4920
Gene Full Name	receptor tyrosine kinase like orphan receptor 2
Gene Alias	BDB; BDB1; NTRKR2
Transcripts	ENSG00000169071
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q01974
HGNC ID	HGNC:10257
VEGA ID	OTTHUMG00000020211
OMIM ID	602337
String ID	9606.ENSP00000364860
PharmGKB ID	PA34629

Target gene [ROR2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010787	chr9	11	18		29	View
6015233	chr9	5	9		14	View
6018498	chr9	9			9	View
6019221	chr9	7	1		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ROR2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ROR2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ROR2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ROR2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ROR2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ROR2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).