HBV Target gene Detail Information

> ROCK1 Gene Search Result

Gene Information

Gene Name	ROCK1
Gene ID	6093
Gene Full Name	Rho associated coiled-coil containing protein kinase 1
Gene Alias	ROCK-I; P160ROCK
Transcripts	ENSG00000067900
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q13464
HGNC ID	HGNC:10251
VEGA ID	OTTHUMG00000131723
OMIM ID	601702
String ID	9606.ENSP00000382697
Drugbank ID	BE0001016
Drug (Cytoscape Annotation)	Ruxolitinib Phosphate;Bosutinib;Sunitinib Malate
PharmGKB ID	PA34623

Target gene [ROCK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1000502	chr18	810	1064	191	2065	View
1000522	chr18	797	1028	185	2010	View
1004296	chr18	83	3		86	View
1004328	chr18	82	3		85	View
1010106	chr18	7	6		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of ROCK1 expression and immune infiltrating cell level correlation result in HBV+ samples
ROCK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).