HTLV1 Target gene Detail Information

> RIN2 Gene Search Result

Gene Information

Gene Name	RIN2
Gene ID	54453
Gene Full Name	Ras and Rab interactor 2
Gene Alias	MACS; RASSF4
Transcripts	ENSG00000132669
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Golgi apparatus;Nucleoli;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q8WYP3
HGNC ID	HGNC:18750
VEGA ID	OTTHUMG00000031996
OMIM ID	610222
String ID	9606.ENSP00000255006
PharmGKB ID	PA38672

Target gene [RIN2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000930	chr20	55	169	477	701	View
6001051	chr10	479	122	17	618	View
6002880	chr20	9	146	47	202	View
6002891	chr20	9	146	46	201	View
6002892	chr20	9	146	46	201	View
6006331	chr20	66	2	2	70	View
6006440	chr20	64	2	2	68	View
6009491	chr20	3	9	24	36	View
6014233	chr12	16	1		17	View
6016152	chr6	9	4		13	View
6022882	chr12	1	1	2	4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of RIN2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
RIN2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of RIN2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
RIN2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of RIN2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
RIN2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).