HIV Target gene Detail Information

> RHOA Gene Search Result

Gene Information

Gene Name	RHOA
Gene ID	387
Gene Full Name	ras homolog family member A
Gene Alias	ARHA; ARH12; RHO12; RHOH12
Transcripts	ENSG00000067560
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P61586
HGNC ID	HGNC:667
VEGA ID	OTTHUMG00000156838
OMIM ID	165390
String ID	9606.ENSP00000400175
Drugbank ID	BE0001190
PharmGKB ID	PA134865095

Target gene [RHOA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002106	chr3	82	10	20	112	View
4002882	chr3	48	28		76	View
4004826	chr3	6	28	5	39	View
4006496	chr3	22	2		24	View
4010321	chr3	7	2		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of RHOA expression and immune infiltrating cell level correlation result in HIV+ samples
RHOA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of RHOA expression and immune infiltrating cell level correlation result in HIV+ samples
RHOA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).