HIV Target gene Detail Information

> RHEB Gene Search Result

Gene Information

Gene Name	RHEB
Gene ID	6009
Gene Full Name	Ras homolog, mTORC1 binding
Gene Alias	RHEB2
Transcripts	ENSG00000106615
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins
Uniport_ID	Q15382
HGNC ID	HGNC:10011
VEGA ID	OTTHUMG00000157330
OMIM ID	601293
String ID	9606.ENSP00000262187
Drugbank ID	BE0004594
PharmGKB ID	PA34389

Target gene [RHEB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000169	chr7	344	145	341	830	View
4004818	chr7	36	3		39	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of RHEB expression and immune infiltrating cell level correlation result in HIV+ samples
RHEB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of RHEB expression and immune infiltrating cell level correlation result in HIV+ samples
RHEB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).