HIV Target gene Detail Information

> REV3L Gene Search Result

Gene Information

Gene Name	REV3L
Gene ID	5980
Gene Full Name	REV3 like, DNA directed polymerase zeta catalytic subunit
Gene Alias	POLZ; REV3
Transcripts	ENSG00000009413
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O60673
HGNC ID	HGNC:9968
VEGA ID	OTTHUMG00000016318
OMIM ID	602776
String ID	9606.ENSP00000351697
PharmGKB ID	PA34337

Target gene [REV3L] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000089	chr6	34	885	249	1168	View
4005490	chr6	8	24		32	View
4006202	chr6	26			26	View
4012507	chr6	3	2		5	View
4016666	chr6				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of REV3L expression and immune infiltrating cell level correlation result in HIV+ samples
REV3L expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of REV3L expression and immune infiltrating cell level correlation result in HIV+ samples
REV3L expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).