HTLV1 Target gene Detail Information

> REC8 Gene Search Result

Gene Information

Gene Name	REC8
Gene ID	9985
Gene Full Name	REC8 meiotic recombination protein
Gene Alias	Rec8p; REC8L1; HR21spB
Transcripts	ENSG00000285007
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	O95072
HGNC ID	HGNC:16879
VEGA ID	OTTHUMG00000171916
OMIM ID	608193
String ID	9606.ENSP00000482546
PharmGKB ID	PA162401009

Target gene [REC8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6008754	chr14	42			42	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of REC8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
REC8 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of REC8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
REC8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).