HIV Target gene Detail Information

> RBL2 Gene Search Result

Gene Information

Gene Name	RBL2
Gene ID	5934
Gene Full Name	RB transcriptional corepressor like 2
Gene Alias	Rb2; P130
Transcripts	ENSG00000103479
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitotic chromosome;Nucleoli rim;Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q08999
HGNC ID	HGNC:9894
VEGA ID	OTTHUMG00000133198
OMIM ID	180203
String ID	9606.ENSP00000262133
PharmGKB ID	PA34258

Target gene [RBL2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005246	chr16	31	3		34	View
4005431	chr16	31	2		33	View
4006482	chr16	24			24	View
4009871	chr16	9	1		10	View
4011451	chr16		7		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of RBL2 expression and immune infiltrating cell level correlation result in HIV+ samples
RBL2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of RBL2 expression and immune infiltrating cell level correlation result in HIV+ samples
RBL2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).