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HBV Target gene Detail Information

> RASGRF2 Gene Search Result


Gene Information
Gene Name RASGRF2
Gene ID 5924
Gene Full Name Ras protein specific guanine nucleotide releasing factor 2
Gene Alias GRF2; RAS-GRF2
Transcripts ENSG00000113319
Virus HBV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;
HPA Protein Class Info Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID O14827
HGNC ID HGNC:9876
VEGA ID OTTHUMG00000119015
OMIM ID 606614
String ID 9606.ENSP00000265080
PharmGKB ID PA34239
Target gene [RASGRF2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1010849 chr5 11 11 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of RASGRF2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
RASGRF2 expression: Low -> High
Lollipop of RASGRF2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of RASGRF2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of RASGRF2 expression and immune infiltrating cell level correlation result in HBV+ samples
RASGRF2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).