HBV Target gene Detail Information

> RAI1 Gene Search Result

Gene Information

Gene Name	RAI1
Gene ID	10743
Gene Full Name	retinoic acid induced 1
Gene Alias	SMS; SMCR
Transcripts	ENSG00000108557
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q7Z5J4
HGNC ID	HGNC:9834
VEGA ID	OTTHUMG00000059314
OMIM ID	607642
String ID	9606.ENSP00000323074
PharmGKB ID	PA34188

Target gene [RAI1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004153	chr17	69	22		91	View
1004434	chr17	21	19	41	81	View
1005241	chr17	20	22	16	58	View
1012381	chr17	7			7	View
1400947	chr17	21	19	41	81	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of RAI1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
RAI1 expression: Low -> High
Lollipop of RAI1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of RAI1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of RAI1 expression and immune infiltrating cell level correlation result in HBV+ samples
RAI1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).