HIV Target gene Detail Information

> RAF1 Gene Search Result

Gene Information

Gene Name	RAF1
Gene ID	5894
Gene Full Name	Raf-1 proto-oncogene, serine/threonine kinase
Gene Alias	NS5; CRAF; Raf-1; c-Raf; CMD1NN
Transcripts	ENSG00000132155
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	P04049
HGNC ID	HGNC:9829
VEGA ID	OTTHUMG00000129789
OMIM ID	164760
String ID	9606.ENSP00000251849
Drugbank ID	BE0000036
PharmGKB ID	PA34183

Target gene [RAF1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001245	chr3	46	81	61	188	View
4004854	chr9	38			38	View
4005368	chr9	33			33	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of RAF1 expression and immune infiltrating cell level correlation result in HIV+ samples
RAF1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of RAF1 expression and immune infiltrating cell level correlation result in HIV+ samples
RAF1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).