HIV Target gene Detail Information

> RAB7A Gene Search Result

Gene Information

Gene Name	RAB7A
Gene ID	7879
Gene Full Name	RAB7A, member RAS oncogene family
Gene Alias	RAB7; PRO2706
Transcripts	ENSG00000075785
Virus	HIV
Gene Type	protein coding
HPA Location Info	Lysosomes;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P51149
HGNC ID	HGNC:9788
VEGA ID	OTTHUMG00000159812
OMIM ID	602298
String ID	9606.ENSP00000265062
Drugbank ID	BE0004485
PharmGKB ID	PA162400619

Target gene [RAB7A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002190	chr3	103	3	1	107	View
4009755	chr3	2	5	4	11	View
4010599	chr3	7		1	8	View
4300020	chr3	35		5	40	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of RAB7A expression and immune infiltrating cell level correlation result in HIV+ samples
RAB7A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of RAB7A expression and immune infiltrating cell level correlation result in HIV+ samples
RAB7A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).