HTLV1 Target gene Detail Information

> RAB27A Gene Search Result

Gene Information

Gene Name	RAB27A
Gene ID	5873
Gene Full Name	RAB27A, member RAS oncogene family
Gene Alias	GS2; RAM; RAB27; HsT18676
Transcripts	ENSG00000069974
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	P51159
HGNC ID	HGNC:9766
VEGA ID	OTTHUMG00000131959
OMIM ID	603868
String ID	9606.ENSP00000379601
PharmGKB ID	PA34117
FDA Approved Drug	Emapalumab-lzsg

Target gene [RAB27A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6023046	chr15	4			4	View
6028278	chr15	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of RAB27A expression and immune infiltrating cell level correlation result in HTLV1+ samples
RAB27A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of RAB27A expression and immune infiltrating cell level correlation result in HTLV1+ samples
RAB27A expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of RAB27A expression and immune infiltrating cell level correlation result in HTLV1+ samples
RAB27A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).