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HTLV1 Target gene Detail Information

> PTPRB Gene Search Result


Gene Information
Gene Name PTPRB
Gene ID 5787
Gene Full Name protein tyrosine phosphatase, receptor type B
Gene Alias PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA
Transcripts ENSG00000127329
Virus HTLV1
Gene Type protein coding
HPA Location Info Plasma membrane;Cell Junctions;Vesicles;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P23467
HGNC ID HGNC:9665
VEGA ID OTTHUMG00000169499
OMIM ID 176882
String ID 9606.ENSP00000334928
Drugbank ID BE0003769
PharmGKB ID PA34010
Target gene [PTPRB] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6006619 chr12 38 13 14 65 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PTPRB expression and immune infiltrating cell level correlation result in HTLV1+ samples
PTPRB expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PTPRB expression and immune infiltrating cell level correlation result in HTLV1+ samples
PTPRB expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PTPRB expression and immune infiltrating cell level correlation result in HTLV1+ samples
PTPRB expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).