HBV Target gene Detail Information

> PTPN2 Gene Search Result

Gene Information

Gene Name	PTPN2
Gene ID	5771
Gene Full Name	protein tyrosine phosphatase, non-receptor type 2
Gene Alias	PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP
Transcripts	ENSG00000175354
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	P17706
HGNC ID	HGNC:9650
VEGA ID	OTTHUMG00000131702
OMIM ID	176887
String ID	9606.ENSP00000311857
PharmGKB ID	PA33993

Target gene [PTPN2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1014081	chr18	3	1		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PTPN2 expression and immune infiltrating cell level correlation result in HBV+ samples
PTPN2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).