Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> PTPN11 Gene Search Result


Gene Information
Gene Name PTPN11
Gene ID 5781
Gene Full Name protein tyrosine phosphatase, non-receptor type 11
Gene Alias CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3
Transcripts ENSG00000179295
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoli rim;Actin filaments;Cytosol;Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Gene Function Suppressor gene & Oncogene
Uniport_ID Q06124
HGNC ID HGNC:9644
VEGA ID OTTHUMG00000134334
OMIM ID 176876
String ID 9606.ENSP00000340944
Drugbank ID BE0001071
PharmGKB ID PA33986
Target gene [PTPN11] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1005780 chr12 28 8 12 48 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PTPN11 expression and immune infiltrating cell level correlation result in HBV+ samples
PTPN11 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).