HBV Target gene Detail Information

> PTK2 Gene Search Result


Gene Information
Gene Name PTK2
Gene ID 5747
Gene Full Name protein tyrosine kinase 2
Gene Alias FAK; FADK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK
Transcripts ENSG00000169398
Virus HBV
Gene Type protein coding
HPA Location Info Focal adhesion sites;Cytosol;Vesicles;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q05397
HGNC ID HGNC:9611
VEGA ID OTTHUMG00000067438
OMIM ID 600758
String ID 9606.ENSP00000341189
Drugbank ID BE0003090
Drug (Cytoscape Annotation) Sunitinib Malate;Bosutinib;Crizotinib
PharmGKB ID PA33955
Target gene [PTK2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002676 chr8 180 43 223 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of PTK2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
PTK2 expression: Low -> High
Lollipop of PTK2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of PTK2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PTK2 expression and immune infiltrating cell level correlation result in HBV+ samples
PTK2 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).