HIV Target gene Detail Information

> PTGES3 Gene Search Result

Gene Information

Gene Name	PTGES3
Gene ID	10728
Gene Full Name	prostaglandin E synthase 3
Gene Alias	P23; TEBP; cPGES
Transcripts	ENSG00000110958
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q15185
HGNC ID	HGNC:16049
VEGA ID	OTTHUMG00000170217
OMIM ID	607061
String ID	9606.ENSP00000482075
Drugbank ID	BE0002480
PharmGKB ID	PA142671118

Target gene [PTGES3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001956	chr12	101	14	6	121	View
4002997	chr12	16	34	22	72	View
4004099	chr12	23	25	1	49	View
4004648	chr12	36	5		41	View
4004941	chr12	27	9	1	37	View
4005327	chr12	5	27	2	34	View
4008110	chr12	11	5		16	View
4008638	chr12	8	1	5	14	View
4013149	chr12	3	1		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PTGES3 expression and immune infiltrating cell level correlation result in HIV+ samples
PTGES3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PTGES3 expression and immune infiltrating cell level correlation result in HIV+ samples
PTGES3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).