HIV Target gene Detail Information

> PSMB8 Gene Search Result

Gene Information

Gene Name	PSMB8
Gene ID	5696
Gene Full Name	proteasome subunit beta 8
Gene Alias	JMP; ALDD; LMP7; NKJO; D6S216; PRAAS1; PSMB5i; RING10; D6S216E
Transcripts	ENSG00000230669
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;Cytokinetic bridge;
HPA Protein Class Info	Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P28062
HGNC ID	HGNC:9545
VEGA ID	OTTHUMG00000012779
OMIM ID	177046
String ID	9606.ENSP00000364016
Drugbank ID	BE0004739
PharmGKB ID	PA33890

Target gene [PSMB8] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Detail
1	33109760	I109A	Nef	View
2	33109760	L110A	Nef	View
3	33109760	D111A	Nef	View
4	33109760	I114A	Nef	View
5	33109760	L112A	Nef	View
6	33109760	Y115A	Nef	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PSMB8 expression and immune infiltrating cell level correlation result in HIV+ samples
PSMB8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PSMB8 expression and immune infiltrating cell level correlation result in HIV+ samples
PSMB8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE17372