HIV Target gene Detail Information

> PSMB4 Gene Search Result

Gene Information

Gene Name	PSMB4
Gene ID	5692
Gene Full Name	proteasome subunit beta 4
Gene Alias	HN3; HsN3; PRAAS3; PROS26; PROS-26
Transcripts	ENSG00000159377
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Mitochondria;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P28070
HGNC ID	HGNC:9541
VEGA ID	OTTHUMG00000012494
OMIM ID	602177
String ID	9606.ENSP00000290541
Drugbank ID	BE0003918
PharmGKB ID	PA33886

Target gene [PSMB4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000088	chr1	1162	11		1173	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PSMB4 expression and immune infiltrating cell level correlation result in HIV+ samples
PSMB4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PSMB4 expression and immune infiltrating cell level correlation result in HIV+ samples
PSMB4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).