HIV Target gene Detail Information

> PSEN1 Gene Search Result

Gene Information

Gene Name	PSEN1
Gene ID	5663
Gene Full Name	presenilin 1
Gene Alias	AD3; FAD; PS1; PS-1; S182; ACNINV3
Transcripts	ENSG00000080815
Virus	HIV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Cell Junctions;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P49768
HGNC ID	HGNC:9508
VEGA ID	OTTHUMG00000141279
OMIM ID	104311
String ID	9606.ENSP00000326366
PharmGKB ID	PA33855

Target gene [PSEN1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008582	chr14	3	10	1	14	View
4013156	chr14	4			4	View
4016495	chr14				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PSEN1 expression and immune infiltrating cell level correlation result in HIV+ samples
PSEN1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PSEN1 expression and immune infiltrating cell level correlation result in HIV+ samples
PSEN1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).