Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> PROC Gene Search Result


Gene Information
Gene Name PROC
Gene ID 5624
Gene Full Name protein C, inactivator of coagulation factors Va and VIIIa
Gene Alias PC; APC; PROC1; THPH3; THPH4
Transcripts ENSG00000115718
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID P04070
HGNC ID HGNC:9451
VEGA ID OTTHUMG00000131528
OMIM ID 612283
String ID 9606.ENSP00000234071
Drugbank ID BE0000380
PharmGKB ID PA33799
FDA Approved Drug Avatrombopag;Estradiol;Progesterone;Lusutrombopag;Synthetic Conjugated Estrogens,A;Warfarin
Target gene [PROC] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1005187 chr2 44 13 2 59 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of PROC expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
PROC expression: Low -> High
Lollipop of PROC expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of PROC expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PROC expression and immune infiltrating cell level correlation result in HBV+ samples
PROC expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).