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EBV Target gene Detail Information

> PRKN Gene Search Result


Gene Information
Gene Name PRKN
Gene ID 5071
Gene Full Name parkin RBR E3 ubiquitin protein ligase
Gene Alias PDJ; AR-JP; LPRS2; PARK2
Transcripts ENSG00000185345
Virus EBV
Gene Type protein coding
HPA Location Info Nuclear speckles;Cytosol;
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function Suppressor gene
Uniport_ID O60260
HGNC ID HGNC:8607
OMIM ID 602544
PharmGKB ID PA32942
Target gene [PRKN] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3000066 chr6 111 45 159 315 View
3000851 chr6 3 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE100458 (GEO) Burkitt lymphoma 14 Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)

> Dataset: GSE100458

HeatMap of cell type fractions in all samples Lollipop of PRKN expression and immune infiltrating cell level correlation result in EBV+ samples
PRKN expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).